Story lines to follow leading up to the game:
Hurtin' for certain: The Colts won't know until later in the week whether they'll be without the services of wide receiver Marvin Harrison (knee), safety Bob Sanders (ribs), tight end Ben Utecht (concussion) and running back Joseph Addai (shoulder). Linebacker Rob Morris (knee) is out.
Indy will get no sympathy from the Bucs. In Sunday's win at Carolina, they lost running back Cadillac Williams (torn right patella tendon) and offensive tackle Luke Petitgout (torn anterior cruciate ligament in right knee).
Chasing another 5-0: The Colts can become just the fourth team in NFL history to open three consecutive seasons with a 5-0 record. They also can set a franchise record with a 12th straight regular-season home win.
Defense in Tampa: The Bucs' defense is in midseason form, ranking first in points allowed (11.0), fifth in total yards allowed (291.8) and sixth in passing yards allowed (173.5). In wins the past two weeks against St. Louis and Carolina, Tampa Bay has allowed 10 points and 481 yards, including only 246 through the air.
Dominating the NFC: Colts quarterback Peyton Manning is 23-14 against the NFC in the regular season, and 16-5 since Dungy's arrival in 2002. Since '02, Manning has compiled a 116.1 rating by completing 69.8 percent of his passes with 57 touchdowns and just 14 interceptions.