Penn State's D has played well besides for a few lapses (2nd Halves against OSU and Ohio, and 2nd and 3rd quarters against NW). I think O'Brien will want to limit the possession and keep his D rested so will try to eat clock on offense.
I thought for sure Mich would hammer Nebraska and prevent them from winning that division. They appear to have a clear path now. Even if they lose to Penn State, if OSU beats Mich Nebraska goes. I've heard Notre Dame is a possible matchup in the Rose Bowl if the Huskers wins the conference. Looking ahead quite a bit for that to happen though.