Candlestick Park
This game will be the first time since "Handshake-Gate" that these two teams will face off. Other than the meeting of two potential playoff foes, this matchup marks a significant game for the 49ers. If construction of the 49ers' new Santa Clara stadium remains on track, this is one of two home openers remaining that the 49ers will host at Candlestick Park. The thing most fans have taken for granted for the last 30-plus years is coming to a quicker end than most may realize.
The Matchup
Its going to be one of the most physical games of the entire season. With the "bad blood" that was boiling after the 49ers' victory in 2011, I wouldn't be surprised to see a lot of aggressiveness by both coaches when it comes to play-calling and strategy. And when it comes to the 49ers defending Calvin Johnson, I expect a lot of press coverage with safety help over the top. If you can disrupt Johnson's route, you have a better chance at stopping him rather than allowing a free release -- not a significantly better chance, but a better chance (after all, it is Calvin Johnson we're talking about).
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Kick his ass Sea Bass