Umpiring crews are usually not announced in advance of the first game of any series.
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| Date: 2018-06-12 | Proj. HP Umpire |
| Boston at Baltimore | Mark Carlson |
| Colorado at Philadelphia | |
| Washington at NY Yankees | |
| Toronto at Tampa Bay | Chad Fairchild |
| Minnesota at Detroit | |
| San Francisco at Miami | Mark Wegner |
| NY Mets at Atlanta | |
| Cleveland at Chi. White Sox | Tom Woodring |
| Chi. Cubs at Milwaukee | |
| Cincinnati at Kansas City | |
| San Diego at St. Louis | Chris Segal |
| Pittsburgh at Arizona | D.J. Reyburn |
| Houston at Oakland | |
| LA Angels at Seattle | Adam Hamari |
| Texas at LA Dodgers |
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