I really believe San Francisco & Miami would struggle with many college teams on the road. San Francisco definately has a worse offense than many college teams. 49'ers would be far superior to any college team defensively.
Miami would also have problems with some college teams especially if the Fish & 49'ers played these teams on the road.
Canes from 2001 would crush about 1/3 of the current NFL squads IMO. Santana Moss, Reggie Wayne, Clinton Portis, Willis McGahee, Bubba Franks, Ed Reed, etc. I think Miami 2001 should be regarded as the most talented college football team of all time.