I see Florida being the overall #1 seed. They have a pretty easy remaining schedule & even if Kentucky beats them the last game of the regular season or in the SEC tournament final, they would only have 3 losses to 32 wins.
Wichita State in my mind can lose a game, maybe even two, and they still will be on the 1 line.
I think Syracuse's luck is about to run out. After BC Wednesday, they have 3 tough road games: Duke, Maryland, and Virginia. At best, I think they go 1-2. And then, the ACC tournament. I feel they WILL NOT win it, so that will put them at 3 losses.
Kind of the same story for Arizona as it is for Syracuse. Remaining road games are: Utah, Colorado, Oregon State, and at Oregon. At best 3-1. Then, the Pac-10 tournament, which they won't win. That will leave them with AT LEAST 4 losses.
I honestly see Kansas & Duke both winning their regular season conferences & tournament titles. I think they will be the other 2 #1's, in addition to Florida & Wichita State.
Will a #1 seed win it all? I say NO. Too much parity in the above mentioned teams! Plus, throw in the likes of Michigan State, Louisville, Villanova, Cincinnati, San Diego State, even Creighton, Kentucky, and UConn & you have 64 teams vs. only 4 teams!! GL