try this i found on google:
do a system save in system before doing it though in case something gets fcked up so you can do a system restore:
If you still have problems, some ISP's provide a customized version of IE. Some Web pages will also reset your home page and do this. One of the customizations they might make is to disable the ability to change the home page, so that you are forced to use their home page. You can re-enable this by making a small change in the Windows registry.
In Regedit, navigate to this key:
HKEY_CURRENT_USER\Software\Policies\Microsoft\Internet Explorer\Control Panel
In the right-hand pane, right-click the "HomePage" value, then select Modify. Change it to: 00 00 00 00
Also change either or these to zero 0 instead of 1 if present:
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\Explorer] - DWORD "NoSetHomePage"=dword:00000001
[HKEY_CURRENT_USER\Software\Policies\Microsoft\Internet Explorer\Restrictions] - DWORD "NoSetHomePage"=dword:00000001
If you don't have this key, browse to:
HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\Main
and in the right hand pane, double click "Local Page" and set equal to "C:\WINDOWS\System\blank.htm" (no quotes) which will hopefully set your Home Page to blank and then allow you to subsequently modify it using Internet Options.
Exit regedit and reboot.
When you reboot, you should be able to change the home page again.
Some pages will also download a program which keeps changing it back. Go to Start | Run and type:
msconfig
and press <Enter> or click OK. Go to the Startup tab.
See if you can identify any suspicious programs. If you can, uncheck it, If you can't, change the home page to what you want and then uncheck one and then reboot. Try IE. If the Web page changed, change it back and then try msconfig again, rechecking the last one and unchecking the next. Keep doing this until you find the culprit.
gl