On wsex, I often play 6 point pleasers, which pay 6/1.
I have found the best way to go about picking these is to find small chalk that you think will win outright... for me, this generally leads to teams that are somewhere between +3 to +7 and playing at home.
I have actually made money on pleasers this year. Not a ton, but I have pulled a profit. I dont believe you can consistantly win by taking favorites and giving more points.
Think about it this way... if you have a team at +3, it will get pleased to -3, but you are essentially receiving a free point, because +1 to 0 and 0 to -1 all count as a point apiece. Wheras if you have a team at -4.5 and please them to -10.5, all of a sudden you have a game that is expected to be played close needing a semi-blowout.
Anyhow, good luck.