CAL's average win this year has been by 32 pts per game despite them playing the #4 ranked strength of schedule. The only loss CAL has suffered was against the #1 ranked team in the country.
CAL is balanced on offense and plays solid defense. CAL going into this game has had back to back shut outs.
Another reason why they might be favored by 22pts is they need to impress the polls. A big victory will get people talking more and more about CAL and the Orange Bowl if OU and AU should lose.
CAL is giving up 17ppg while scoring an average of 39ppg. That is a difference of 22ppg and the spread against Oregon is 22pts.
Oh yeah, this game is AT CAL!