For me the biggest issues are the wars in Iraq and Afghanistan, Plus health care. Leaving 50,000 soldiers in Iraq is not ending the war and WTF are we doing in Afghanistan?
Health care can be the one issue that can make America greater. 100 years from now, whoever gets it done always be remembered for doing a great service for the country.
The American government is rotten and will be for a long time to come. People thought Rome would never fall, but it did. America prizes money above all else so it too days are numbered.
I think the rest of the world won't miss the US once it's gone.