Stanford normally plays decent offense at home, so I think USC would have to shut them out to cover this line, which I personally don't see happening. The first two games this year they have scored around 40 both times, and Yes these teams are not quiet the caliber of USC. USC just hasn't impressed me yet either and Stanford should come ready for this one. Also I really look at teams that have a possibility of looking ahead, Well CAL comes to USC in two weeks and not only is it probably the game deciding the PAC-10 but a huge revenge game for USC in the fact that CAL basically kept them from the BCS National Title Game. With that said I truthfully think USC looks past Stanford even though the CAL game is in two weeks. That along with 22 points on your home field in Stanford's biggest game of the year. I am only playing this as a 3* and if I had to give a score I'd say.
USC 38 STAN 21
just my 2 cents though