It all depends on how much you want to spend. If you want a nice room in a nice hotel you want to try Wynn/Bellagio/Cosmopolitan, if you want party atmosphere the Hard Rock (off strip) or Mandalay Bay, if you want center of it all I would go Bally's (older) or Planet Hollywood.
Stay midweek if you can Sun-Thurs...if not prices jump on Fri and Sat---especially if there is a convention in town....
good luck in your search, it can be a bit overwhelming...