I'm going with 3 pretty sizeable dogs today:
Angels - risky play w/ Santana coming back from that knee injury, but I believe he can out duel Padilla if he's actually healthy.
Orioles - The O's got to Mussina the last time they faced him. If they can provide some runs for Bedard, he can turn his luck around from going 0-3 despite some good pitching in his recent outings.
Royals - this pick by itself is equivalent to one of those "what the heck" parlays. Hernandez actually went 7 innings in a somewhat decent outing last time. I have a strange feeling he can do something similar against another potent offense, while Vazquez has one of his 5 and done outings.
With the size of these three, a 2-1 day will be pretty good. Good luck.