any !*^$#%n herb smokers left in these ruins?

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Fucking Wednesday, right. Wednesday is next year, ain't it?
Offseason blues.


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Damn it, I'm trying to make sense of the antagonism between dopamine and endocannabinoids, but my conversation with AI on this matter has, apparently, broken both of us.

Endocannabinoids as neuromodulators and retrograde neurotransmitters.
I get it.

Most of the remaining biochemical word salad was over my head.
I cannot judge the legitimacy of the confusion within its other answers, but I'm taking this one as a hint:

me: which neurons, in the brain, don't have cb1 receptors?

AI:
AI Overview
Learn more

In the brain, astrocytes, oligodendrocytes, oligodendrocyte precursor cells (OPCs), and adult neural stem cells (NSCs) generally lack CB1 receptors, or express them at very low levels. While CB1 receptors are abundant in many brain regions, including the cortex, hippocampus, basal ganglia, and cerebellum, they are not found in these glial cell types.

Oops, something went wrong.

====================================================================
I hope so.
Refreshing gave same cold comfort.

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und is German, nein?

I was stupidly looking up a potentially incorrect labelling and discovered that this Dunst disc, from 2013, is presently listed at bandcamp at "name your own price."

I'm blessed with now having to find another song, not because of that whatever but because I was going to share one of the better talks I've heard on cannabinoid science, health, etc. Interview, actually, not talk.

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Misleading title on that interview. I think Huberman is contra (he's contra most fun), but guest Hill is an advocate. I confess I'm only halfway through so its a Bananarama edit if I find it ends poorly.

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AI and I are having confusion over the use of the word "receptor."

In a lock and key situation, the receptor would be the lock, no?

Neurotransmitters, like keys, would have an affinity to interact with the binding locations on neurons--the locks--but a key can't unlock another key as the key has no receptor, as the lock does.

AI will stupidly answer ill-phrased questions, without any recognition of such detraction. I think I got around that problem. Maybe I just failed the wrong college course.

We pay the price for thinkin'

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maybe slap a couple from 1997 disc Tumuli Shroomaroom

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title seemed appropriate. too old for these guys on a Sunday, testing

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Not the best musically, that Acrimony, but its the lead singer that doesn't keep me coming back.

Dude with these guys a little better, but they never owned me, either. A few others I liked by them but now can't find or was not worthy.

Maniacally is a word that just came to mind.
No, not the song. The cure is ugly.


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Fuck, I ain't crazy about that anymore, either.

I should try and stumble through the rest of that interview.

On the stoner rock vein, close it with a couple from these guys that I can't leave out. Not long-lived before disbanding and forming Queens of the Stone Age etc, but Kyuss' limited play worked for me, or is it their limited work played for me. Rhetorical silence.

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lil' longer here

shit...this copy with the lame-ass hidden track seems best quality. You can see why I don't need their closing, comedic routine and once owned a stellar, 8-minute, copy

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Should go back and sanitize this thread. Frayed fucking edges of sanity.

Not a good advocate for the herb.
Not a good salesman for the tunes.

Not my fucking fault.


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Stuck with me until 7. Then I get to revisit some bullshit.
 

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Good news. Friendly neighborhood postman secured me my stash. Not small.
So, why the boozeurge? World? Head? None since Friday.

Trying to think about something clever to say about Charlie. Never learn.


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They say Exposure Therapy works for fear, but I would like to avoid any spiders.


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As aging, I got to be in the mood to listen to those guys.
I am.

Missed this fucker, so far, somehow. Seems quaint.

He had a lot of nothing to say


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division separation disharmony discord

Saving for laters imaginary journal entry.

I vote the harmony one.

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Unfortunately, or not, this next one ain't about the herb.

About hypocrisy. Sorta follows, but I went in with the wrong question. One step passed the pot calling the kettle black.

Googleyed for my pleasue:

me: origin of pot calling kettle black

not me:
The idiom "the pot calling the kettle black" originated in Thomas Shelton's 1620 translation of Miguel de Cervantes's Don Quixote. It refers to a situation where someone criticizes another for a fault that they themselves possess.


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