Damn it, I'm trying to make sense of the antagonism between dopamine and endocannabinoids, but my conversation with AI on this matter has, apparently, broken both of us.
Endocannabinoids as neuromodulators and retrograde neurotransmitters.
I get it.
Most of the remaining biochemical word salad was over my head.
I cannot judge the legitimacy of the confusion within its other answers, but I'm taking this one as a hint:
me: which neurons, in the brain, don't have cb1 receptors?
AI:
AI Overview
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In the brain, astrocytes, oligodendrocytes, oligodendrocyte precursor cells (OPCs), and adult neural stem cells (NSCs) generally lack CB1 receptors, or express them at very low levels. While CB1 receptors are abundant in many brain regions, including the cortex, hippocampus, basal ganglia, and cerebellum, they are not found in these glial cell types.
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I hope so.
Refreshing gave same cold comfort.