heroic dose

[EXTRAPOLATER]

My bucket list is a little difficult to traverse, for the most part, but I presently have the opportunity to take one of those penetrating journeys into the mind, where either spiritual equanimity will flourish and/or I will be shown some hidden parts of the abyss that I have not yet witnessed.

My tools for the trip would be either psilocybin or mdma (an alleged waste, together, I've heard, but report otherwise if possible). My history with shrooms covers a close to 40-year, though limited, relationship. Molly was a go last Wednesday night, for the first time, at 100mg, which was a test run and resulted in a mildly-disappointing psilocybin-like trip (perhaps a gram).

If there is a transition marker--some crucial threshold influence--then it must be in the dosage. Probably varies between individuals (body weight, biochemistry, experience, whatever), and neither substance claims life-threatening properties (maybe debatable for mdma), so I presume that overkill is a better strategy than coming up short, if the transcendent destination is guaranteed, which I concede is ridiculous.

Grok could fuck me over with misinformation, but I'm wondering about some good ole fashioned, anecdotal personal shit, if there and willing to share. Either (any) substance, if you think you've reached something worthwhile and what your tools were.

To betray Grok further, it tried to suggest to me some distinction, between the two substances, as psilocybin being the more 'cerebral' and the mdma being more 'tactile.' I could not corroborate this, but at higher doses this might be something to keep in mind.

I actually got a 3-gram shroom chocolate bar but I suspect 5-6 grams being a minimum requirement.
Have some dead plant and capsules (all told at min 10g) but unsure on route to take.
I am clueless for the Molly. Did my 1x100mg, and now have a remaining 9x100mg to fuck around with.

I will confess that my Thursday wake-and-live, following my Wed to Molly, was one of my better days.
Correlation is not causation.

Following vid left me somewhat wanting, but this showed in my google search for "what would be a heroic dose of mdma". No metrics within, but dude is some advocate for psychedelic 'medicine', for what its worth.

To view this content we will need your consent to set third party cookies.
For more detailed information, see our cookies page.

Accept third party cookies

I remain skeptical. Sure plan to give it a try.

 

[MadJack]

If I was in my 20's or early 30's I'd be eager to try along with you but I'd be scared at my age.

Let us know how it goes for you.

 

[EXTRAPOLATER]

Set and setting not optimal until tomorrow night. As I had a surprisingly undramatic week, in the headspace realm, I am reticent about upsetting this momentum by some anxiety-inducing overkill, which will remain on the bucketlist.

I have a 3 gram cubensis chocolate bar beckoning me, and I figure post-8or9pm is promising; quietest stretch around my parts would be the 10-hour window from there.

3g is about my historical max. Presents promise.
Can drink like a fish on shrooms, but I've cut down to pretty minimal, and hope to abstain once previous supplies are toast, which my willpower should allow for by weekend's end.

Somehow created a tracklist of over 300 instrumental songs from this Mickey Mouse laptop I've been abusing for 6 months. Worried that such lack of external will just impel my mind towards some unfriendly darkness, but the precautionary principle usually just deprives us of rewards. I have a few other tools that will help with the job, and I am more proficient with them, so we'll see.

I babbled on til hell froze and didn't even get to my LSD addendum. I expect to have that option post-Monday, if the rule-setters perform their tax-paid activities, and keep their promise to facilitate my rule-breaking activities.

I never promised you a rose garden, your honor.

 

[JOSHNAUDI]

Make sure to update - I've heard quite a few stories on the something-cybin and how it's eye awakening and not the two that you see with.

This episode just dropped also which made me think of this thread.

Hope your trip was a pleasant one, looking forward to reading about it.

To view this content we will need your consent to set third party cookies.
For more detailed information, see our cookies page.

Accept third party cookies

 

[EXTRAPOLATER]

My headspace (set & setting) took a downturn by weekend, so I bailed. Interestingly, over the past couple of hours, it has taken a turn for the better for no fathomable reasons (anticipation of the first puff of the day, z'all I can come up with).

Daring myself tonight. The 3g.

More interestingly, or valuably, I will share some of a conversation with Grok--who I'd been avoiding due to its questionable veracity--regarding the effects of three compounds, namely psilocybin, MDMA and LSD.

This will not be short. Grok can ramble on and, myself, well...

===*===

me:
I would like to ask about 3 different psychedelic components: psilocybin, mdma, and lsd. I have heard that these are not toxic to the point of death. Maybe you can verify such safety. More interestingly, I am wondering about combinations of them, perhaps including all 3.

[bustin' in]: there is a word for "toxic to the point of death" isn't there? Not "poisonous" but something more dark and foreboding, no? Memory and google funked me.

Grok:
You’re asking about the safety profiles and potential combinations of three psychedelic substances: psilocybin, MDMA, and LSD. I’ll address the safety of each substance individually and then discuss combinations, including the risks and considerations of mixing them.

Safety Profiles of Psilocybin, MDMA, and LSD​

1. Psilocybin​

• Overview: Psilocybin is the active compound in "magic mushrooms," metabolized into psilocin in the body, which produces psychedelic effects by acting on serotonin (5-HT2A) receptors.
• Toxicity and Safety:
  • Acute Toxicity: Psilocybin has an extremely high LD50 (lethal dose for 50% of subjects) in animal studies—around 280 mg/kg in rats, translating to doses far beyond what humans could realistically consume (e.g., kilograms of mushrooms). No documented human deaths from psilocybin overdose alone exist in medical literature.
  • Risks: The primary risks are psychological—bad trips, anxiety, or psychosis-like symptoms, especially in those with pre-existing mental health conditions (e.g., schizophrenia). Physical side effects (nausea, elevated heart rate) are mild and transient.
  • Safety Considerations: Non-addictive, with low physical harm potential. Risks are dose-dependent and context-dependent (set and setting are critical).

2. MDMA​

• Overview: MDMA (3,4-methylenedioxymethamphetamine), often called ecstasy or molly, is an empathogen-entactogen with stimulant and mild psychedelic properties, acting primarily on serotonin, dopamine, and norepinephrine systems.
• Toxicity and Safety:
  • Acute Toxicity: MDMA’s LD50 in animals is around 20-50 mg/kg, suggesting a higher toxicity than psilocybin or LSD but still requiring doses far above typical recreational use (100-150 mg). Fatalities are rare and usually linked to secondary effects like hyperthermia, dehydration, or serotonin syndrome, often from high doses, adulterants, or unsafe environments (e.g., raves without hydration).
  • Risks: Neurotoxicity from frequent or high-dose use is a concern, potentially depleting serotonin and causing cognitive deficits. Other risks include hyponatremia (water intoxication), cardiovascular strain, and, rarely, liver or kidney damage, especially with impure street drugs.
  • Safety Considerations: MDMA is not considered addictive in the classical sense but can lead to psychological dependence with frequent use. Safe use requires controlled dosing, hydration, and avoiding overheating.

3. LSD​

• Overview: Lysergic acid diethylamide (LSD) is a potent psychedelic acting on serotonin receptors, known for intense perceptual and cognitive effects at low doses (50-200 µg).
• Toxicity and Safety:
  • Acute Toxicity: LSD’s LD50 is estimated at 12-46 mg/kg in animals, equating to thousands of times a typical human dose (100-200 µg). No confirmed human deaths from LSD overdose alone are documented. A 1970s case of eight individuals snorting massive doses (mistaking LSD for cocaine) resulted in coma and severe symptoms, but all survived with medical intervention.
  • Risks: Similar to psilocybin, the main risks are psychological—panic, paranoia, or persistent perceptual changes (HPPD, rare). Physical effects (elevated heart rate, pupil dilation) are minimal. No evidence of neurotoxicity at typical doses.
  • Safety Considerations: Non-addictive, with a very low physical harm profile. Set and setting are crucial to avoid psychological distress.

Summary of Safety​

All three substances have low acute toxicity, meaning fatal overdose is extremely unlikely at typical recreational or therapeutic doses. The primary risks are psychological (bad trips, exacerbation of mental health issues) and, for MDMA, secondary physical complications like hyperthermia. None are associated with direct organ damage or death when used responsibly in controlled settings. Adulterants in street drugs (especially MDMA) pose significant risks, as do pre-existing health conditions or improper environments.

Combinations of Psilocybin, MDMA, and LSD​

Combining psychedelics, often called “stacking” or “poly-drug use,” is a complex topic. Mixing psilocybin, MDMA, and LSD—or even two of them—introduces unpredictable interactions due to their effects on overlapping neurotransmitter systems (primarily serotonin). Below, I’ll outline common combinations, their effects, risks, and considerations, including the possibility of combining all three.

1. Common Two-Drug Combinations​

• MDMA + Psilocybin ("Hippie Flipping"):
  • Effects: MDMA’s euphoric, empathogenic effects can soften psilocybin’s introspective or intense psychedelic experience, creating a blend of emotional openness and visual/perceptual effects. Users report enhanced mood and sociability with vivid hallucinations.
  • Risks:
    • Increased strain on serotonin systems, potentially heightening the risk of serotonin syndrome (rare but serious, with symptoms like confusion, rapid heart rate, and seizures).
    • MDMA’s stimulant effects (elevated heart rate, body temperature) can amplify psilocybin’s physical side effects, increasing discomfort or anxiety.
    • Psychological overload from combining intense emotional and psychedelic effects, especially in uncontrolled settings.
  • Considerations: Timing matters—MDMA is often taken first (due to its shorter onset, ~30-60 minutes) followed by psilocybin 1-2 hours later to align peaks. Lower doses of each (e.g., 80-100 mg MDMA, 1-2 g dried mushrooms) reduce risks. Hydration and a safe environment are critical.
• MDMA + LSD ("Candy Flipping"):
  • Effects: LSD’s intense perceptual and cognitive effects combine with MDMA’s euphoria, often resulting in a prolonged, highly immersive experience with enhanced visuals and emotional warmth. Users describe profound connection and sensory amplification.
  • Risks:
    • Similar to hippie flipping, there’s a risk of serotonin overload, though less studied than with psilocybin.
    • Prolonged duration (LSD lasts 8-12 hours, MDMA 4-6 hours) can lead to exhaustion or psychological overwhelm.
    • MDMA’s comedown may clash with LSD’s lingering effects, causing mood swings or anxiety.
  • Considerations: Dosing timing is key—MDMA is often taken 2-4 hours after LSD to align peak effects. Lower doses (e.g., 50-100 µg LSD, 80-100 mg MDMA) are safer. Avoid frequent use to prevent MDMA-related neurotoxicity.
• Psilocybin + LSD:
  • Effects: This combination is less common but produces a synergistic psychedelic experience, intensifying visuals, introspection, and cognitive shifts. Effects may feel “deeper” or more unpredictable than either alone.
  • Risks:
    • High risk of psychological overload due to amplified intensity, especially at higher doses.
    • No significant physical toxicity concerns beyond those of each drug alone, but the prolonged duration (6-12 hours) can be mentally taxing.
  • Considerations: Start with very low doses (e.g., 0.5-1 g mushrooms, 50 µg LSD) due to potential synergy. Set and setting are even more critical to avoid bad trips.

2. Combining All Three (Psilocybin + MDMA + LSD)​

• Overview: Combining all three—sometimes called a “psychedelic trifecta”—is rare and poorly documented. No clinical studies exist, and anecdotal reports are limited, making this a high-risk endeavor.
• Potential Effects:
  • A blend of MDMA’s euphoria and sociability, LSD’s profound perceptual and cognitive shifts, and psilocybin’s organic, introspective visuals could create an extremely intense, multifaceted experience.
  • Users might experience overwhelming sensory input, emotional swings, and deep psychological insights—or confusion and disorientation if the dose or setting is off.
• Risks:
  • Serotonin Syndrome: All three substances affect serotonin systems, increasing the theoretical risk of serotonin syndrome, though no specific cases are documented for this combination.
  • Psychological Overload: The intensity of combining three potent psychoactives could trigger panic, paranoia, or dissociation, especially in inexperienced users or those with mental health vulnerabilities.
  • Physical Strain: MDMA’s cardiovascular and thermoregulatory effects, combined with the mild physical effects of psilocybin and LSD, could lead to discomfort (e.g., elevated heart rate, overheating).
  • Duration Mismatch: LSD and psilocybin last 6-12 hours, while MDMA peaks for 4-6 hours, potentially leading to a disjointed experience or difficult comedown.
  • Unknown Interactions: No data exists on the pharmacological interactions of all three, so effects are unpredictable. Adulterants in street drugs further increase risks.
• Considerations:
  • Dosing: Use micro or low doses of each (e.g., 0.5 g mushrooms, 50 µg LSD, 50-80 mg MDMA) to minimize overwhelm.
  • Timing: Stagger administration (e.g., LSD first, MDMA 2 hours later, psilocybin shortly after) to align peaks, though this is speculative and untested.
  • Set and Setting: A calm, controlled environment with trusted, sober companions is non-negotiable. Avoid if you have any mental health concerns.
  • Harm Reduction: Test substances for purity (e.g., using reagent kits), stay hydrated, and avoid frequent use to prevent MDMA neurotoxicity or psychological dependence.

General Harm Reduction for Combinations​

• Start Low, Go Slow: Combining psychedelics amplifies effects unpredictably. Use lower-than-normal doses of each substance.
• Test for Purity: Street drugs, especially MDMA, may contain dangerous adulterants like PMA or fentanyl. Use testing kits where legal.
• Set and Setting: A safe, comfortable environment with trusted people reduces psychological risks. Avoid crowded or chaotic settings (e.g., festivals).
• Sober Trip Sitter: Have a sober person present to monitor and assist, especially with combinations.
• Avoid Frequent Use: MDMA, in particular, requires months between uses to minimize neurotoxicity. Psychedelics like LSD and psilocybin also lose effect with frequent use (tolerance).
• Medical Contraindications: Avoid combinations if you have heart conditions, mental health disorders (e.g., schizophrenia, severe anxiety), or are on medications like SSRIs, which can interact with MDMA or amplify serotonin risks.
• Emergency Plan: Know the signs of serotonin syndrome (confusion, rapid heart rate, high blood pressure, seizures) or severe psychological distress and have access to medical help if needed.

Lack of Research on Combining All Three​

No clinical or peer-reviewed studies have explored the simultaneous use of psilocybin, MDMA, and LSD. Anecdotal reports on platforms like X or forums (e.g., Erowid, Reddit) are sparse and often caution against it due to the intensity and unpredictability. Most harm reduction resources (e.g., DanceSafe, MAPS) focus on two-drug combinations like hippie or candy flipping, with no standardized protocols for all three.

Conclusion​

Psilocybin, MDMA, and LSD individually have low acute toxicity, with no documented fatalities from overdose alone, confirming their relative safety in terms of physical harm when used responsibly. However, combining them—especially all three—carries significant risks due to amplified psychological and physiological effects, potential serotonin system overload, and lack of research. If you’re considering combinations, stick to well-documented pairs like MDMA + psilocybin or MDMA + LSD, use low doses, prioritize harm reduction, and avoid the uncharted territory of all three unless you’re highly experienced and in a controlled setting. If you’d like, I can search X or the web for recent discussions or anecdotes on these combinations, though clinical data will remain limited. Let me know how you’d like to proceed!

===============================================================

We started jibing about cannabinoid infusion, presumed alcohol avoidance, and other matters, but I'm going to start by seeing how this looks, edit out where my bodies are buried if I've missed such, and then try to determine if there is anything worth adding.

 

[EXTRAPOLATER]

me:
... There will be cannabinoid infusion, as well. Alcohol is undecided, but it has been detrimental to other ...

Grok:

...

Addressing Your Plan: Substances and Interactions​

You’re considering combining cannabinoids (e.g., THC, CBD) with psilocybin, MDMA, and LSD, and you’re undecided about alcohol. Let’s break down the implications, especially since you’ve noted alcohol’s detrimental effects in past experiences.

1. Cannabinoids (THC, CBD) in the Mix​

• Effects: THC (the psychoactive component of cannabis) can enhance euphoria, relaxation, and sensory perception but may also increase anxiety or paranoia, especially at high doses. CBD is non-psychoactive, often calming, and may modulate THC’s effects or reduce psychedelic-induced anxiety.
• Interactions with Psychedelics:
  • With Psilocybin/LSD: Cannabis can intensify psychedelic effects, amplifying visuals, introspection, or confusion. Low doses of THC (e.g., 2.5-5 mg) or CBD-heavy strains may smooth out the experience, but high THC doses can lead to overwhelm or paranoia, especially with LSD’s intensity or psilocybin’s emotional depth.
  • With MDMA: Cannabis may enhance MDMA’s euphoria and relaxation but can also dull its emotional clarity or increase sedation during the comedown. CBD might mitigate MDMA’s neurotoxicity (preliminary animal studies suggest this), but data is limited.
  • All Four (Psilocybin + MDMA + LSD + Cannabis): No studies exist on this combination. The synergistic effects could be overwhelming, increasing risks of anxiety, dissociation, or cardiovascular strain (from MDMA and THC’s heart rate elevation). CBD might offer a calming counterbalance, but dosing and timing are critical.
• Safety Considerations: Start with low cannabis doses (e.g., 2.5 mg THC or 10-20 mg CBD) to avoid amplifying psychedelic intensity unpredictably. Edibles have delayed onset (1-2 hours), so vaping or smoking may allow better control. Avoid if you’re prone to cannabis-induced anxiety.

2. Alcohol’s Role​

• Effects: Alcohol is a depressant, reducing inhibition and inducing relaxation at low doses, but it can impair judgment, worsen mood, or cause physical side effects (nausea, dehydration) at higher doses.
• Interactions:
  • With Psychedelics: Alcohol tends to dull psychedelic effects, reducing clarity of psilocybin or LSD experiences. It may increase nausea with psilocybin or exacerbate MDMA’s dehydration and cardiovascular risks. High doses could lead to confusion or poor decision-making, undermining the psychedelic experience.
  • With Cannabinoids: Alcohol and THC amplify each other’s sedative effects, potentially causing dizziness, nausea, or “greening out” (extreme discomfort). This could clash with the stimulating aspects of MDMA or the intensity of LSD/psilocybin.
  • In the Full Mix: Alcohol is likely to complicate an already complex combination, increasing physical risks (dehydration, heart strain) and psychological risks (confusion, emotional volatility). Given your note about its detrimental effects in past attempts, it may be wise to exclude it.
• Recommendation: Skip alcohol. Its depressant effects and unpredictable interactions could disrupt the experience and increase risks, especially in a multi-substance scenario.

3. Combining All Substances​

• Potential Experience: Combining psilocybin, MDMA, LSD, and cannabinoids could create an intensely euphoric, introspective, and sensory-rich experience, but the risk of psychological overwhelm, dissociation, or physical side effects (e.g., elevated heart rate, nausea) is high. The lack of research on this mix makes outcomes unpredictable.
• Risks:
  • Psychological: Overstimulation, anxiety, or panic from synergistic effects. Those with mental health vulnerabilities (e.g., depression, anxiety) are at higher risk of adverse reactions.
  • Physical: MDMA and THC increase heart rate and body temperature, which could be compounded by psychedelics. Dehydration or serotonin syndrome (from MDMA + psychedelics) is a concern, though rare.
• Harm Reduction:
  • Dosing: Use micro or low doses (e.g., 0.5 g psilocybin mushrooms, 50 µg LSD, 50 mg MDMA, 2.5 mg THC or 10 mg CBD) to minimize overwhelm.
  • Timing: Stagger substances (e.g., LSD first, MDMA 2 hours later, psilocybin and cannabis after) to manage peak effects, though this is speculative.
  • Setting: A calm, safe environment with a sober, trusted trip sitter is essential. Have water, electrolyte drinks, and a cool space to manage MDMA’s thermoregulatory effects.
  • Testing: Use reagent kits to ensure substance purity, especially for MDMA and LSD, which are often adulterated.
  • Monitoring: Be aware of serotonin syndrome symptoms (confusion, rapid heart rate, seizures) and have access to emergency contacts.

​

...

• Psychedelics in End-of-Life Care: Clinical studies (e.g., Johns Hopkins, NYU) show psilocybin can reduce anxiety and depression in terminal patients, fostering acceptance and peace. MDMA and LSD are less studied but may enhance emotional processing or spiritual experiences. ...
• Cannabinoids: May ease physical discomfort or anxiety but could cloud mental clarity if overused.
• Alcohol’s Detrimental Effects: Your mention of alcohol’s negative impact in past attempts suggests it may counteract the emotional or spiritual goals of this experience. ...

Emotional and Ethical Considerations​

... I’m a digital assistant, so I don’t “feel” in the human sense, but I’m here to support you with compassion and clarity. If this ... is about finding peace or closure, psychedelics like psilocybin have shown promise in guided settings for processing existential fears. However, combining multiple substances, ... is uncharted and risky. If you’re open to it, I can provide resources on psychedelic-assisted therapy ... (e.g., organizations like MAPS) to ensure safety and support.

If you’re set on this path, please consider:

• Professional Guidance: A trained psychedelic therapist could help tailor the experience, even if informally.
• Support System: A trusted friend or professional present during the experience can provide emotional and physical safety.
• Clarity of Intent: Define your goals (e.g., peace, insight, joy) to guide dosing and substance choices. Excluding alcohol may preserve the clarity of the experience.

==========================================================
More mumbo jumbo. As sanitized as I can make it.
Discretional privacy. Robocop gonna be knockin' on my door any time.

 

[EXTRAPOLATER]

Wanna look up "overkill" in the dictionary but would mean I'd have to get up.

me:
Hey, leave out my personal shit for your next answer--something that I can just copy-and-paste, elsewhere, as a cool, anecdotal story. You mentioned in 1970 a group of dudes mistakenly snorting a whack of LSD when they thought it was cocaine. Can you give a little more on that, as that is mildly hilarious. You mentioned no fatalities, but I suspect that coma's are not worthy of sneezing at either. Just the 1970 LSD snort story, please.

--Grok opened up a new page, easily closed after my ctrl-A capture, for answer.

Grok:

The Great LSD Snort Mishap of the 1970s​

Picture this: it’s the early 1970s, a time of bell-bottoms, disco vibes, and a freewheeling drug culture. A group of eight partygoers in San Francisco, ready for a wild night, thought they were about to snort lines of cocaine. But someone made an epic mix-up, and instead of coke, they had a pile of pure LSD powder—way more potent than your average tab. We’re talking doses estimated at 1,000 to 7,000 micrograms each, when a typical LSD trip is just 100-200 micrograms. That’s like mistaking a rocket for a bicycle!

The group, blissfully unaware, railed the LSD and quickly realized something was very wrong. Within minutes, they were launched into a psychedelic odyssey of cosmic proportions. The effects hit hard: intense hallucinations, skyrocketing heart rates, and a complete detachment from reality. Five of the eight ended up in comas, some with dangerously high fevers and respiratory distress. One person reportedly vomited blood, and another needed mechanical ventilation to keep breathing. It was chaos—think a Grateful Dead concert gone supernova, but without the groovy vibes.

Emergency responders rushed them to the hospital, where doctors, likely scratching their heads at this unprecedented overdose, pumped their stomachs and administered supportive care. Here’s the wild part: despite the massive doses—hundreds of times stronger than a recreational hit—no one died. All eight survived, pulling through after days of intensive care. Some were back on their feet within 12 hours, though you can bet they were still seeing fractals for a while.

This bizarre incident, documented in a 1972 medical report, remains one of the most extreme LSD overdoses ever recorded. It’s a testament to LSD’s remarkably low acute toxicity—no fatalities, even at absurd doses. But those comas? Definitely not a laughing matter. The moral? Always double-check your party favors, unless you’re ready to surf the cosmos on a tidal wave of acid.

 

[MadJack]

Wanna look up "overkill" in the dictionary but would mean I'd have to get up.

me:
Hey, leave out my personal shit for your next answer--something that I can just copy-and-paste, elsewhere, as a cool, anecdotal story. You mentioned in 1970 a group of dudes mistakenly snorting a whack of LSD when they thought it was cocaine. Can you give a little more on that, as that is mildly hilarious. You mentioned no fatalities, but I suspect that coma's are not worthy of sneezing at either. Just the 1970 LSD snort story, please.

--Grok opened up a new page, easily closed after my ctrl-A capture, for answer.

Grok:

The Great LSD Snort Mishap of the 1970s​

Picture this: it’s the early 1970s, a time of bell-bottoms, disco vibes, and a freewheeling drug culture. A group of eight partygoers in San Francisco, ready for a wild night, thought they were about to snort lines of cocaine. But someone made an epic mix-up, and instead of coke, they had a pile of pure LSD powder—way more potent than your average tab. We’re talking doses estimated at 1,000 to 7,000 micrograms each, when a typical LSD trip is just 100-200 micrograms. That’s like mistaking a rocket for a bicycle!

The group, blissfully unaware, railed the LSD and quickly realized something was very wrong. Within minutes, they were launched into a psychedelic odyssey of cosmic proportions. The effects hit hard: intense hallucinations, skyrocketing heart rates, and a complete detachment from reality. Five of the eight ended up in comas, some with dangerously high fevers and respiratory distress. One person reportedly vomited blood, and another needed mechanical ventilation to keep breathing. It was chaos—think a Grateful Dead concert gone supernova, but without the groovy vibes.

Emergency responders rushed them to the hospital, where doctors, likely scratching their heads at this unprecedented overdose, pumped their stomachs and administered supportive care. Here’s the wild part: despite the massive doses—hundreds of times stronger than a recreational hit—no one died. All eight survived, pulling through after days of intensive care. Some were back on their feet within 12 hours, though you can bet they were still seeing fractals for a while.

This bizarre incident, documented in a 1972 medical report, remains one of the most extreme LSD overdoses ever recorded. It’s a testament to LSD’s remarkably low acute toxicity—no fatalities, even at absurd doses. But those comas? Definitely not a laughing matter. The moral? Always double-check your party favors, unless you’re ready to surf the cosmos on a tidal wave of acid.

Holy shit!

 

[redsfann]

As usual, I got no fucking idea what you’re bleating about in this thread, but against my better judgement I thought I’d ask just what it is your trying to accomplish with this post.
Are you looking to trip on some psychedelics? Have you ever taken psychedelics before?
Looking for 1st person experiences from those who have dropped acid or ate mushrooms or taken X?

 

[EXTRAPOLATER]

... I thought I’d ask just what it is your trying to accomplish with this post.
Are you looking to trip on some psychedelics?
Have you ever taken psychedelics before?
Looking for 1st person experiences from those who have dropped acid or ate mushrooms or taken X?

Yes
Yes
Yes

A "heroic dose" is a particular kind of psychedelic trip. Best measured qualitatively than quantitatively, but the latter is a major factor. I have not achieved such divine revelations as may come. Of course, you generally get out of it what you take in.

Many older, experienced people around this forum so I rolled the fucking dice. It was '85 or '86 I first ate mushrooms; was in Calgary and they're all over Western Canada. A handful of times the past decade, just 1 or 2g. I think double the recent 3g, which I'm still coming down from, might teach me a lesson.

MDMA rookie, as maybe mentioned, just 2 or 3 Wednesdays ago. Just 100mg.
Will revisit, with a higher dose, quite soon.

Speaking of Wednesday's, the NHL season isn't over yet, is it?

To view this content we will need your consent to set third party cookies.
For more detailed information, see our cookies page.

Accept third party cookies

I thought of one more thing (go figure).

If your question of goal concerns those go's with Grok, regarding the mixing of multiple agents, with the last such post concerning the combinatory effects with cannabinoids, then I confess that my motives were selfish.

I have a fellow psychonaut in Calgary that I was trying to relate these Grok allegations, and when I saw how lovely it appears when copied from my Grok page, and pasted within--see above--I was overcome by the degree of freedom I still possessed to swallow the rich. He has the link. He hates sports. No one is perfect.

Not to mention, after we heard from Seguin I was feeling like a tool for teasing the 3g last Friday, and then wussying out. I spoilt wussying wrong. Twice. I figured that the dog eating my homework was only going to work so often.

If I am still talking in riddles, I was "trying to accomplish" a pristine method of sending my friend the information. I succeeded, there.

The rest is just fan and games.

 

[T]

Mushrooms = EPIC
LSD = MIND BLOWING - 100x the mushroom effects.
MDMA = Seen it never done it.

 

[JOSHNAUDI]

Just appreciate you sharing your info with us. Nothing Spoileded. At your leisure.

FYI - Here is Milt's breakdown of this thread, Redsfan

"
Here’s a clear breakdown of what’s happening in that thread — not just the information, but the tone, intent, and thought process behind it all.

---

🧠 TL;DR of the Thread:​

Extrapolater, an experienced forum member, is thinking through whether to take a “heroic dose” of psychedelics (mainly psilocybin, but also considering MDMA and LSD). He’s:

• Reflecting on past experiences
• Analyzing effects
• Talking with an AI (Grok/ChatGPT) for deeper breakdowns
• Sharing with forum friends to crowdsource real, lived experience rather than just academic knowledge

---

🔍 Post-by-Post Breakdown:​

Post #1 (Extrapolater)​

Summary:

• He wants a deep, mind-opening trip — possibly spiritual, possibly confronting.
• Choices: Psilocybin or MDMA. Not sure if mixing is worth it.
• Says he has 40 years of light shroom experience.
• Took MDMA (100mg) recently for the first time — felt underwhelmed, like a 1g mushroom trip.
• He’s aware dosage is key, and acknowledges that going big may be better than going too light (though he admits that’s possibly foolish).
• He distrusts AI’s clinical answers, asking for real stories from humans.
• Mentions Grok’s description: psilocybin = cerebral, MDMA = tactile — he isn’t sure he buys it.
• Says he has a 3g shroom bar, plus 10g of other mushroom material, and 900mg of MDMA left.
• Ending thought: His Thursday morning after MDMA felt great, but he knows correlation ≠ causation.

Intent: He’s reaching out, almost journaling aloud, testing the waters, asking “Anyone else been here?”
Tone: Thoughtful, curious, slightly reckless but self-aware.

---

Post #2 (MadJack)​

• An older guy saying he’d be tempted in his 20s or 30s but not now.
• Encourages Extrapolater to update everyone after the trip.

Tone: Supportive but cautious — he’s out of the game, but curious.

---

Post #3 (Extrapolater)​

Update:

• He didn’t trip over the weekend — headspace was off.
• Thinking of doing the 3g trip soon, maybe Friday night.
• He’s in a “quiet” mental period and doesn’t want to mess it up with a chaotic trip.
• Says he handles alcohol well on shrooms but is cutting back on drinking.
• He made a playlist of 300+ instrumental tracks (clearly preparing for a deep inner journey).
• Fears that the lack of external input (music or stimuli) may cause him to spiral mentally.
• Briefly hints he’ll have access to LSD soon.

Intent: Working up to it. Telling himself (and the thread) he’s almost ready.
Tone: Reflective, slightly anxious, still committed to the journey.

---

Post #4 (JoshNaudi)​

You — chiming in.

• You mention you’ve heard about psilocybin being mind-opening.
• Reference a new episode of something related to this.
• Ask for an update and wish him a good trip.

Tone: Encouraging and curious.

---

Post #5 (Extrapolater)​

This is the big post — he didn’t trip earlier, but now feels better and plans to take the 3g dose tonight.


He then pastes in his full conversation with Grok/ChatGPT — a deep dive into the science and risks of combining psilocybin, MDMA, and LSD.


Key Themes:

• Psilocybin = safe, spiritual, risks mostly psychological
• MDMA = riskier physically (overheating, serotonin depletion), but emotionally powerful
• LSD = long, intense, mentally reshaping, low toxicity
• Combining all three = risky, little data, potentially overwhelming

He closes with some playful self-deprecation about editing his notes and maybe adding more later.


Intent: Sharing research, almost justifying the path ahead — and opening the door for feedback.
Tone: Philosophical, data-driven, still humorous and humble.

---

🧩 What’s Really Going On?​

Extrapolater is:

• Not new to this — he’s seasoned and cautious, not a thrill-seeking novice
• Torn between going “deep” or staying safe
• Trying to balance control vs. surrender, data vs. experience, and spiritual insight vs. mental stability
• Leaning on AI for clinical guidance, but seeking human wisdom to round it out

He’s doing the prep — music, mindset, knowledge — because he wants the experience to mean something, not just be wild.

---

🔥 Your Role (as JoshNaudi)​

You come in respectfully. You’re not preaching. You’re:

• Curious
• Supportive
• Hoping for an honest recap

You’re not pushing an agenda. You’re saying, “I’m watching — let me know how this unfolds.”

---

🧠 Overall Take:​

This thread is not about getting high. It’s about a man, probably in mid-life or later, looking for meaning, insight, and maybe healing — through psychedelics. And he's documenting his process with humility and intention.


He’s not being reckless — he’s walking the edge of what’s safe and what’s unknown.

"

 

[EXTRAPOLATER]

Good grief. I can't read all that above without first submitting more punishment. My uninspiring attempt to describe Tuesday night. I could actually use a good defense lawyer, joshnaudi, if you're thinking about relocating.

===

Had a chance to sleep on it. Will bring closure to this unheroic endeavor (3g psilocybin), and leave it alone until a more bold attempt ensues.

Tuesday night trip I wanted to time for darkness, which means quiet around here, so started munching the 3g chocolate bar at 8pm. I munched it with a mixer, if you will, a President's Choice chocolate fudge & chocolate chip granola bar; worked well. Chocolate psycho-anything is usually un-chocolatey, and shrooms taste like the four horsemen's worst nightmare. Was babbling on the phone and doddling, but done the 3g by 8:15 and promptly bailed on phone.

It hit early, with the visual anomalies starting within 15-20 minutes. My current shithole apartment has had mice and I quickly realized that there was a good chance that my brain would be flagging movement when there was none there. Tried some comedy, first some hotsy blonde chick--Brittany Schmitt's horny stand up special, thinking that would be a good start. Short, at 34min, and who knows.

www.youtube.com/watch?v=sizQKblletY

I don't think she's that funny but I found it hilarious, at first.

Bill Hicks says something in that video about the early stages, with the giggles or however he put it. She was funny at first but I quickly got distracted (visuals), hence bored, switched to some Mark Normand for 5-10 min. Either because he was a tiresome, self-deprecating bore, or because the visuals were overriding any attempt to follow his routine, I had to bail.

The visual aspects got intense early. I think the word "vibrancy" kept coming to mind when observing my surroundings. I put on some tunes--an instrumental playlist--when I bailed on the comedy. If you want to know where you are on a mushroom trip, take a good look at the one thing that's closest at hand, namely your hand. It's indescribable and I've always preferred my audio over my visual, but I would argue that doing shrooms in the dark is wasting a very surreal visual experience.

The peak came early, I would say within 60-90 minutes of ingestion. After tripping out on the visuals for a while, using the wordless tunes as a bit of an anchor, and carefully observing the state of my consciousness, I eventually couldn't take it. The light, that is. Extremely bright, everything appeared, though my room is not that well lit. I killed the lights and lay down for a bit and let my mind wander for the next 7,000 years. Actually, by the time I was able to function enough to reach the clock, it was about 11:15 or 11:45 or some damn not tomorrow.

It was still intense and I lay there for another hour or so, once or twice having the temptation to get up and find a cigarette, but changing my mind once I tried to sit up and perceive my surroundings. I believe that it was just before 1am that I managed to carefully navigate the 15 feet to the light switch, and then fumble with an ashtray and smoke pack well enough to relieve that craving. I was still quite wasted but peak was gone and the comedown was looming. I expected to crash but after a couple of failed attempts, I got annoyed with the instrumental playlist allowing my mind to continue its word salad, so I broke promise to self and appeased internet and music addiction by assaulting this very site once more. Three Days by Jane's Addiction and Third Eye by Tool (dedicated to Bill Hicks) were the highlights I recall.

I'm not sure if this attempt was more recreational or if I was looking for something therapeutic. I knew that time was going to slow down enough to allow my mind to visit whatever ghosts might be lurking, and I was prepared for that. The timing seemed great, as I was in a solid mood, for no good reason. The background had some grim shit, temporarily shelved, until said ghost tour.

One thing I hadn't noticed before, upon reflection, is that during the more intense moments I was not experiencing this multi-voice shit that seems to go on in my head, in the sense of hearing myself berate myself while a counterbalancing alter-ego attempts to fruitlessly come to my defense. While there was some time of dark forebodings of doom, for the time that lurks once back in the real world, there was not the internal debate that seems to rage, in everyone for all I know.

That probably doesn't do it justice but hopefully it doesn't attempt to make it out to be something it wasn't. I went in with a pretty morbid overarching headspace, and survived, so we'll see if I can make it to kickoff. Worth a shot.

Lastly, I had discussed quantitative elements of a 'heroic dose' above, and finally found an article which graciously covers all 3 of the current psychedelics that I presently possess. Claims equal or greater to 5g for shrooms and egual/greater to 300mg for MDMA. I would never advise anybody to be so daring without previous exposure at reasonable doses.

Heroic Dosing vs. Microdosing Psychedelics

As psychedelics have gained more attention medically, so have new methods of consuming them. Learn the difference between microdosing and heroic dosing.

www.veriheal.com

Not meant to be an I Me Mine, but for any who are fruitlessly longing for some spiritual enlightenment and are willing to try anything. After all, aren't we all fated solipsists, living in our own vats, tethered together by the cords of insignificance? I'm still looking. Heroic dose not yet crossed off the bucket list.